All kick-off times in GMT.
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- Wed, Feb 22, 2012
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| 2011/2012 Coastal Stream | |||
|---|---|---|---|
| FT | Benoni Premier Utd | 0 - 0 | Nathi Lions |
| FT | Carara Kicks | 2 - 2 | Blackburn Rovers |
| FT | F.C A.K | 1 - 2 | United FC |
| FT | FC Cape Town | 3 - 1 | Dynamos |
| FT | Vasco Da Gama | 3 - 1 | Bay United |
| FT | Mpumalanga Black Aces | 1 - 0 | African Warriors |
| FT | Pretoria Univ | 0 - 2 | Chippa United |
| FT | Sivutsa Stars | 0 - 1 | Witbank Spurs |